Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis.

@article{TunyogiCsap2007RoleOF,
  title={Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis.},
  author={Mikl{\'o}s Tunyogi-Csap{\'o} and Tam{\'a}s Koreny and Csaba Vermes and Jorge O. Galante and Joshua.J. Jacobs and Tibor T. Glant},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2007},
  volume={25 10},
  pages={1378-88}
}
The periprosthetic granulomatous soft tissue [designated iterfacial membrane (IFM) in this study] exhibits heterogeneous histopathological features, in which highly vascularized areas with dense cellularity alternate with fibrotic and pseudocapsule-like tissue structures. Although macrophage/monocyte activation is a prominent event in the periprosthetic environment, fibroblasts also phagocytose particulate wear debris both in vivo and in vitro. Particulate wear debris and/or cytokines/growth… CONTINUE READING

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