Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis.

@article{Yu2003RoleOF,
  title={Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis.},
  author={Chundong Yu and Fen Wang and Chengliu Jin and Xinqiang Huang and David Lee Miller and Claudio Basilico and Wallace L. Mckeehan},
  journal={The American journal of pathology},
  year={2003},
  volume={163 4},
  pages={1653-62}
}
Genomic ablation of hepatocyte-specific fibroblast growth factor receptor (FGFR)4 in mice revealed a role of FGF signaling in cholesterol and bile acid metabolism and hepatolobular restoration in response to injury without effect on liver development or hepatocyte proliferation. Although the potential role of all 23 FGF polypeptides in the liver is still unclear, the most widely studied prototypes, FGF1 and FGF2, are present and have been implicated in liver cell growth and function in vitro… CONTINUE READING