Role of fibroblast growth factor receptors in astrocytic stem cells.

  title={Role of fibroblast growth factor receptors in astrocytic stem cells.},
  author={Alma Y Galvez-Contreras and Roc{\'i}o Elizabeth Gonz{\'a}lez-Casta{\~n}eda and Sonia Luqu{\'i}n and Oscar Gonzalez-Perez},
  journal={Current signal transduction therapy},
  volume={7 1},
There are two well-defined neurogenic regions in the adult brain, the subventricular zone (SVZ) lining the lateral wall of the lateral ventricles and, the subgranular zone (SGZ) in the dentate gyrus at the hippocampus. Within these neurogenic regions, there are neural stem cells with astrocytic characteristics, which actively respond to the basic fibroblast growth factor (bFGF, FGF2 or FGF-β) by increasing their proliferation, survival and differentiation, both in vivo and in vitro. FGF2 binds… CONTINUE READING


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