Role of fibroblast growth factor 8 in neurite outgrowth from spiral ganglion neurons in vitro.

@article{GarcaHernndez2013RoleOF,
  title={Role of fibroblast growth factor 8 in neurite outgrowth from spiral ganglion neurons in vitro.},
  author={Sof{\'i}a Garc{\'i}a-Hern{\'a}ndez and Steven J Potashner and D. Kent Morest},
  journal={Brain research},
  year={2013},
  volume={1529},
  pages={39-45}
}
Many neurons degenerate after injuries resulting from overstimulation, drugs, genetic mutations, and aging. Although several growth factors and neurotrophins delay degeneration and promote regrowth of neural processes, the role of fibroblast growth factor 8 (FGF8) in mammalian spiral ganglion neurons (SGN) neurite outgrowth has not been examined. This study develops and uses SGN cell cultures suitable for experimental analysis, it investigates whether FGF8a and FGF8b isoforms affect the neurite… CONTINUE READING