Role of fibrinogen in complement inhibition by streptococcal M protein.

@article{Horstmann1992RoleOF,
  title={Role of fibrinogen in complement inhibition by streptococcal M protein.},
  author={R Horstmann and H J Sievertsen and Matthias Leippe and Vincent A. Fischetti},
  journal={Infection and immunity},
  year={1992},
  volume={60 12},
  pages={5036-41}
}
M protein, the major virulence factor of group A streptococci, has antiopsonic activity in that it inhibits activation of the alternative complement pathway on the streptococcal surface. Two properties of M protein have been claimed to account for the inhibitory activity, namely, (i) its binding affinity for complement factor H, which is an inhibitor of alternative pathway activation, and (ii) its high binding affinity for fibrinogen. We have recently shown that fibrinogen, like M protein… CONTINUE READING