Role of fibrinogen-, factor VIII- and XIII-mediated clot propagation in gelatin haemodilution.

@article{Schramko2009RoleOF,
  title={Role of fibrinogen-, factor VIII- and XIII-mediated clot propagation in gelatin haemodilution.},
  author={Alexey A Schramko and Anne Hellevi Kuitunen and Raili Tuulikki Suojaranta-Ylinen and Tomi Tapio Niemi},
  journal={Acta anaesthesiologica Scandinavica},
  year={2009},
  volume={53 6},
  pages={731-5}
}
BACKGROUND Gelatin solution impairs coagulation. The mechanism of coagulopathy is incompletely defined. The purpose of this study was to evaluate the capacity of single coagulation factors to reverse gelatin-promoted whole-blood coagulation disorders in vitro. METHODS Venous blood was withdrawn from 12 volunteers in a crossover study. Four percent succinylated gelatin was added to citrated whole-blood samples to make a 40 vol% end-concentration of gelatin. The baseline and 40 vol% samples… CONTINUE READING
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