Role of fertilization promoting peptide (FPP) in modulating mammalian sperm function.

@article{Fraser1998RoleOF,
  title={Role of fertilization promoting peptide (FPP) in modulating mammalian sperm function.},
  author={Lynn R. Fraser},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={1998},
  volume={3},
  pages={
          D1187-91
        }
}
  • L. Fraser
  • Published 1 December 1998
  • Biology
  • Frontiers in bioscience : a journal and virtual library
Fertilization promoting peptide (FPP), structurally similar to thyrotrophin releasing hormone, is produced by the prostate gland and secreted into seminal plasma. Recent in vitro studies have provided evidence that FPP elicits biologically relevant responses in mouse, human and boar spermatozoa. In the presence of nanomolar concentrations of FPP, spermatozoa become fertilizing more quickly and then are inhibited from undergoing spontaneous acrosome loss, an event that would make them non… 
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연구목적: 정자의 첨체상태는 수정능과 상관관계가 있다. 본 연구는 사람 정자의 동결보존 시 Fertilization promoting peptide (FPP) 처리가 첨체 유지에 효과가 있는지를 알아보고자 실시하였다. 연구재료 및 방법: 사람 정자는 정액검사를 의뢰한 시료를 사용하였으며, 적정농도를 조사하기 위하 여 25, 50, 100 nM FPP를…
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References

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FPP modulates mammalian sperm function via TCP‐11 and the adenylyl cyclase/cAMP pathway
TLDR
The results support the hypotheses that TCP‐11 is the receptor for FPP and that FPP↔TCP‐11 interactions modulate AC/cAMP.
A possible mechanism of action for fertilization promoting peptide, a TRH‐related tripeptide that promotes capacitation and fertilizing ability in mammalian spermatozoa
TLDR
It is suggested that FPP and adenosine, by modulating adenylate cyclase activity to promote capacitation but inhibit spontaneous acrosomal exocytosis, may provide an endogenous mechanism that helps to optimize the fertilizing potential of the few sperm cells that reach the site of fertilization in vivo.
Fertilization promoting peptide, a tripeptide similar to thyrotrophin-releasing hormone, stimulates the capacitation and fertilizing ability of human spermatozoa in vitro.
TLDR
Evidence is obtained that FPP can also promote the capacitation and fertilizing ability of ejaculated human spermatozoa in vitro and the presence of FPP in human seminal plasma at concentrations similar to those used here suggests that, in vivo, FPP may play a positive role in promoting human sperm function.
A fertilization promoting peptide (FPP)‐related tripeptide competitively inhibits responses to FPP: A cause of male subfertility?
TLDR
The results suggest that the relative proportions of FPP and related peptides in seminal plasma could have a significant effect on fertility in vivo and conclude that the specific structure of the FPP molecule is crucial for biological activity.
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Stimulating effect of pyroglutamylglutamylprolineamide, a prostatic, TRH‐related tripeptide, on mouse sperm capacitation and fertilizing ability in vitro
TLDR
It is proposed that this prostatic tripeptide with structural similarities to thyrotrophin‐releasing hormone be referred to as fertilization promoting peptide (FPP), because it is possible that it plays a similar role in vivo and promotes fertilizing ability of ejaculated spermatozoa.
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TLDR
The reversibility of some of the mechanisms leading to sperm capacitation may be a very important aspect of the fine regulation and perfect timing of this process.
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TLDR
The results suggest the existence of a stimulatory adenosine receptor site (Ra) on mouse sperm adenylate cyclase that is expressed in uncapacitated spermatozoa and an inhibitory receptors site (Ri) that is expression in capacitated cells, with guanine nucleotides modifying the final response toadenosine.
TCP‐11, the product of a mouse t‐complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction
TLDR
It is suggested that TCP‐11 may be the receptor for FPP and that the adenylate clyclase/cyclic AMP pathway maybe the signal transduction pathway activated by interactions between extracellular effector molecules (e.g., Fab fragments or FPP acting as an agonist) and TCP‐ 11.
Adenosine analogues with specificity for A2 receptors bind to mouse spermatozoa and stimulate adenylate cyclase activity in uncapacitated suspensions.
TLDR
Evidence is provided that [3H]5'-N-ethylcarboxamidoadenosine (NECA), an adenosine analogue with specificity for stimulatory A2Adenosine receptors, can bind to mouse spermatozoa and that both NECA and 2-chloroadenosines significantly stimulated adenylate cyclase activity in a concentration-dependent manner.
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