Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli.

@article{Rock2003RoleOF,
  title={Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli.},
  author={Charles O Rock and Hee Won Park and Suzanne Jackowski},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 11},
  pages={3410-5}
}
Pantothenate kinase (CoaA) is a key regulator of coenzyme A (CoA) biosynthesis in Escherichia coli, and its activity is controlled by feedback inhibition by CoA and its thioesters. The importance of feedback inhibition in the control of the intracellular CoA levels was tested by constructing three site-directed mutants of CoaA that were predicted to be feedback resistant based on the crystal structure of the CoaA-CoA binary complex. CoaA[R106A], CoaA[H177Q], and CoaA[F247V] were purified and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Similar Papers

Loading similar papers…