Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease.

@article{Mcneil2013RoleOF,
  title={Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease.},
  author={Lisa K Mcneil and Robert J. Zagursky and Shuo Liang Lin and Ellen Murphy and Gary W Zlotnick and Susan K Hoiseth and Kathrin Ute Jansen and Annaliesa S. Anderson},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2013},
  volume={77 2},
  pages={234-52}
}
Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans and can cause devastating invasive disease. Although capsular polysaccharide-based vaccines against serogroups A, C, Y, and W135 are widely available, the pathway to a broadly protective vaccine against serogroup B has been more complex. The last 11 years has seen the discovery and development of the N. meningitidis serogroup B (MnB) outer membrane protein factor H binding protein (fHBP) as a vaccine… CONTINUE READING