Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model.

@article{Santangelo2004RoleOE,
  title={Role of extracellular phospholipases and mononuclear phagocytes in dissemination of cryptococcosis in a murine model.},
  author={Rosemary T Santangelo and Hans Zoellner and Tania Christine Sorrell and Christabel Wilson and Christine Donald and Julianne Teresa Djordjevic and Yi Shounan and Lesley Wright},
  journal={Infection and immunity},
  year={2004},
  volume={72 4},
  pages={2229-39}
}
Secreted phospholipase B (PLB) activity promotes the survival and replication of Cryptococcus neoformans in macrophages in vitro. We therefore investigated the role of mononuclear phagocytes and cryptococcal PLB in the dissemination of infection in a mouse model, using C. neoformans var. grubii wild-type strain H99, a PLB1 deletion mutant (Delta plb1), and a reconstituted strain (Delta plb1(rec)). PLB facilitated the entry of endotracheally administered cryptococci into lung IM. PLB was also… CONTINUE READING

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