Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury.

@article{Hart2008RoleOE,
  title={Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury.},
  author={Melanie L. Hart and Martina Henn and David A. Koehler and Doris Kloor and Michel Mittelbronn and Iris C. Gorzolla and Gregory L Stahl and Holger K. Eltzschig},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2008},
  volume={22 8},
  pages={
          2784-97
        }
}
Extracellular adenosine has been implicated as an innate antiinflammatory metabolite, particularly during conditions of limited oxygen availability such as ischemia. Because extracellular adenosine generation is primarily produced via phosphohydrolysis from its precursor molecule adenosine-monophosphate (AMP) through the enzyme ecto-5'-nucleotidase (CD73), we examined the contribution of CD73-dependent adenosine production in modulation of intestinal ischemia-reperfusion (IR) injury. Following… CONTINUE READING
47 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Hypoxia-inducible factor as a physiological regulator

  • P. H. Maxwell
  • Exp. Physiol
  • 2005
Highly Influential
9 Excerpts

Similar Papers

Loading similar papers…