Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas.

@article{Smith2008RoleOE,
  title={Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas.},
  author={Justin S. Smith and Edward F. Chang and Kathleen R. Lamborn and Susan M. Chang and M. Prados and Soonmee Cha and Tarik Tihan and Scott R. Vandenberg and M.W. McDermott and Mitchel S. Berger},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 8},
  pages={
          1338-45
        }
}
  • Justin S. Smith, E. Chang, +7 authors M. Berger
  • Published 10 March 2008
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE The prognostic role of extent of resection (EOR) of low-grade gliomas (LGGs) is a major controversy. We designed a retrospective study to assess the influence of EOR on long-term outcomes of LGGs. PATIENTS AND METHODS The study population (N = 216) included adults undergoing initial resection of hemispheric LGG. Region-of-interest analysis was performed to measure tumor volumes based on fluid-attenuated inversion-recovery (FLAIR) imaging. RESULTS Median preoperative and… 
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The Value of Pre- and Intraoperative Adjuncts on the Extent of Resection of Hemispheric Low-Grade Gliomas: A Retrospective Analysis.
TLDR
Using DES in combination with fMRI and DTI significantly improves EOR when LGGs are located in eloquent areas compared with craniotomies in which only NN was used.
The assessment of prognostic factors in surgical treatment of low-grade gliomas: A prospective study
Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping
TLDR
A significant association between tumor EOR and survival in patients with GII/III gliomas is demonstrated and treatments that are more intensive will be needed for the control of these tumors.
Contemporary assessment of extent of resection in molecularly defined categories of diffuse low-grade glioma: a volumetric analysis.
TLDR
The results corroborate the role of EOR in survival and malignant transformation across all molecular subtypes of diffuse LGG and patients could potentially benefit from a more aggressive surgical approach.
Functional Outcomes in Patients with Low Grade Gliomas ; The Effect of the Extent of Resection
TLDR
The importance of the extent of resection, the preoperative neurological status, the eloquence of the affected cortical area, and thePreoperative determination of the resectable area by the use of preoperative functional MRI, and tractography, with integration of intraoperative navigation techniques for proper excision and preservation of high postoperative quality of life are highlighted.
Updated therapeutic strategy for adult low-grade glioma stratified by resection and tumor subtype.
TLDR
If surgery resulted in EOR <90%, patients with astrocytoma will require second-look surgery, whereas patients with oligodendroglioma or oligoastrocyToma, which are sensitive to chemotherapy, will be treated with chemotherapy.
The benefit of early surgery on overall survival in incidental low grade glioma patients: a multicenter study.
TLDR
This multicenter study confirms the results of previous studies investigating surgical management of iLGGs and thereby strengthens the evidence in favour of early surgery for these lesions.
EXTENT OF SURGICAL RESECTION IS INDEPENDENTLY ASSOCIATED WITH SURVIVAL IN PATIENTS WITH HEMISPHERIC INFILTRATING LOW‐GRADE GLIOMAS
TLDR
GTR was associated with a delay in tumor progression and malignant degeneration as well as improved OS independent of age, degree of disability, histological subtype, or revision versus primary resection.
Comparative volumetric analysis of the extent of resection of molecularly and histologically distinct low grade gliomas and its role on survival
TLDR
Increased EOR is associated with improved OS and PFS survival outcomes, while 1p/19q co-deletion provides improved MPFS.
Extent of resection in diffuse low-grade gliomas and the role of tumor molecular signature—a systematic review of the literature
TLDR
This systematic review of the literature about EOR in different molecular groups of DLGG suggests a benefit of maximum safe resection for all different subtypes, even though “radical surgery” may be associated with better OS and MPFS in tumors with a more aggressive signature.
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