Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.

@article{Ferguson1997RoleOE,
  title={Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.},
  author={Anne T. Ferguson and P M Vertino and J. R. Spitzner and Stephen B. Baylin and M. T. Muller and Nancy E. Davidson},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 51},
  pages={32260-6}
}
The cytosine analog 5-aza-2'-deoxycytidine is a potent inhibitor of DNA methyltransferase. Its cytotoxicity has been attributed to several possible mechanisms including reexpression of growth suppressor genes and formation of covalent adducts between DNA methyltransferase and 5-aza-2'-deoxycytidine-substituted DNA which may lead to steric inhibition of DNA function. In this study, we use a panel of human breast cancer cell lines as a model system to examine the relative contribution of two… CONTINUE READING
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