Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse.

@article{Thurmond2000RoleOE,
  title={Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse.},
  author={T Scott Thurmond and Francis G. Murante and Jennifer Staples and Allen E. Silverstone and Kenneth S. Korach and Thomas A Gasiewicz},
  journal={Endocrinology},
  year={2000},
  volume={141 7},
  pages={2309-18}
}
Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ERalpha knockout (ER-/-), wild-type (ER+/+), and radiation chimeric (ERalpha positive or negative in either nonhematopoietic or hematopoietic elements, or both) male mice were used… CONTINUE READING

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