Role of estrogen receptor-alpha and -beta in regulating leptin expression in 3T3-L1 adipocytes.

@article{Yi2008RoleOE,
  title={Role of estrogen receptor-alpha and -beta in regulating leptin expression in 3T3-L1 adipocytes.},
  author={Kyong Wook Yi and Jung-Ho Shin and Hong Seog Seo and Jae Kwan Lee and Min Jeong Oh and Tak Kim and Ho Suk Saw and Sun-Haeng Kim and J Hur},
  journal={Obesity},
  year={2008},
  volume={16 11},
  pages={
          2393-9
        }
}
We investigated the effects of the estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in the regulation of leptin, resistin, and adiponectin expression in 3T3-L1 adipocytes. Mature adipocytes were exposed to estradiol (E2), ERalpha agonist (PPT (4,4',4''-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol)), ERbeta agonist (DPN (2,3-bis(4-Hydroxyphenyl)-propionitrile)), E2 with ERalpha antagonist (MPP (1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride… CONTINUE READING