Role of estrogen in controlling the genital microflora of female rats

  title={Role of estrogen in controlling the genital microflora of female rats},
  author={Bryan Larsen and A. J. Markovetz and Rudolph P. Galask},
  journal={Applied and Environmental Microbiology},
  pages={534 - 540}
Plate counts of viable bacteria recovered by lavage from rat vaginae demonstrated that the number of bacteria associated with the vaginal epithelium varied cyclically and that this pattern was abolished by ovariectomy. After ovariectomy, vaginal bacterial counts remained relatively stable at low levels. The estrogen 17beta-estradiol (1,3,5(10)-estratriene-3,17beta-diol cypionate) administered to ovariectomized rats caused a significant increase in vaginal bacterial counts on day 3 post… 

Hormonal modulation of the vaginal bacterial flora in experimental polycystic ovarian disease

It is demonstrated that loss of cyclic ovarian activity in PCO rats with persistent estrus causes increased bacterial colonization of the vaginal‐cervical mucosa, and the ovarian hormones appear to modulate the colonization of bacteria in the lower genital tract.

Hormone Therapy Alters the Composition of the Vaginal Microflora in Ovariectomized Rats

Ovariectomy modifies the vaginal microbial profile, and hormone replacement therapy based mainly on schemes containing EE2 could alleviate this disturbance, it is shown that substantial differences exist in the vaginal bacterial microflora between ovariectomized and normal cyclic rats.

Stress modifies the vaginal flora in cyclic female rats

The data showed that stress acting on the vaginal flora and its immunity potential may contribute to disturbances of the natural balance in the area by altering the numbers of several bacteria that belong to the vaginal microflora.

Effects of estrogen administration on the colonization capability of lactobacilli and Escherichia coli in the urinary tracts of mice.

The vaginal environment is a dynamic and complex ecological system with a highly heterogeneous microflora; thus favorable conditions exist for the colonization process, which is also affected by factors external to the tissues.

The externalization of vaginal fatty acids by the female rhesus monkey

A trend for the acid content of the wipes to increase at mid-cycle was consistent with there being an increased flow of secretions to the outside at this time, which is consonant with a role for these acids in signaling the fertile period to the male.

Epithelium of Female Rats: Transmission Electron Microscopy

It is demonstrated bacteriologically and by means of scanning electron microscopy that estrogen treatment of castrate rats is accompanied by changes in the cellular composition of the vaginal epithelium and increased bacterial colonization of the vagina.

Is there a role for lactobacilli in prevention of urogenital and intestinal infections?

Using Lactobacillus strains resistant to Nonoxynol-9, a spermicide that kills members of the protective normal vaginal flora, may have potential for use in women with recurrent cystitis using this contraceptive agent.

Estradiol-17β Pharmacokinetics and Histological Assessment of the Ovaries and Uterine Horns following Intramuscular Administration of Estradiol Cypionate in Feral Cats

Following the administration of a long-acting estrogen, estradiol cypionate, to nine captive feral cats, blood estrogen concentrations remained elevated for several days, and the duration increased with increasing dose.

Characterization of a Hormone-Responsive Organotypic Human Vaginal Tissue Model

Findings indicate that EpiVaginal tissues are hormone responsive and can be used to study the role of female reproductive hormones in innate immune responses, microbial infection, and drug delivery in the vaginal mucosa.

Experimental vaginal colonization and mother-infant transmission of group B streptococci in rats

An animal model for group B streptococcal vaginal colonization and neonatal acquisition was developed with albino rats and significantly more infants born to mothers with positive vaginal cultures acquired the organisms than infants of culture-negative mothers who were suckled by positive adoptive mothers.



Quantitative alterations in the genital microflora of female rats in relation to the estrous cycle.

These studies represent the first reported demonstration that physiologic changes occurring during the estrous cycle control the size of the bacterial population of the vagina.

The Influence of Estrogenic Hormone on the H-Ion Concentration and Bacterial Flora of the Vagina of the Immature Monkey *

It is found that the vaginalsecretions become definitely acid in cases of vulvovaginitis treated with estrogenic hormone and that Gram-negative diplococci disappeared from the genital tract when the pH was depressed to about 6.0, thus indicating that the efficacy of hormone treatment of this disease depends largely on the production of an acid reaction of the vaginal secretions.

The bactericidal action of beta progesterone.

  • M. L. Koch
  • Medicine, Biology
    American journal of obstetrics and gynecology
  • 1950

Estrogen secretion by the rat ovary in vivo during the estrous cycle and pregnancy.

The changes in estrogen concentration in ovarian venous plasma were similar but the major peak on the day of proestrus was sharper, being at about 1000 to 1500 hr on account of changes in blood flow.

Diethylstilbestrol: A Suppressor of Induced Furunculosis in Rabbits

It was demonstrated that natural and acquired antibody formation may be increased during pregnancy and it was pointed out that the peak production of bactericidal substances against anthrax bacilli occurred when estrogenic hormones were most concentrated, that is, in the last few weeks of pregnancy.

Alteration in the multiplication of Staphylococcus aureus by enovid.

In vitro turbidimetric studies indicated that norethynodrel in therapeutic doses had a bacteriostatic action on the growth of staphylococci, and during the first several days after infection the Enovid-treated mice showed reduced mortality rates in comparison to those observed in the control mice.

Effect of Progesterone on Neisseria gonorrhoeae

The effects of progesterone on the growth of pathogenic and nonpathogenic species of Neisseria were studied in liquid cultures. Only strains of N. gonorrhoeae and N. meningitidis were highly

The Incidence of the Döderlein Vaginal Bacillus During the Post-Climacterium *

The vaginal bacillus, a Gram-positive, non-sporulating, aciduric rod, similar in many respects to the intestinal L. acidophilus, was first described by Albert Doderlein in 1892, and was regarded by him the sole organism in the vaginal flora during pregnancy.

An Evaluation of Diethylstilbestrol as an Inhibitor of the Growth of Staphylococci †

Whether diethylstilbestrol, a pure and readily available synthetic estrogen used for replacement therapy in estrogen deficiency, cancer, acne, and other disorders, had any recognizable action on the growth and metabolism of staphylococci is investigated.

Interference with cellular incorporation of substrates into Staphylococcus aureus by hormones.

It appears as if the hormones directly influence the passage of nutrients into bacterial cells with subsequent effects on the incorporation of the nutrients into diverse cellular macromolecules, related to the previously reported antimicrobial effects of hormones on staphylococci.