Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.

@article{Taioli1999RoleOE,
  title={Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.},
  author={Emanuela Taioli and H. Leon Bradlow and Samantha Garbers and Daniel Wayne Sepkovic and Michael P. Osborne and Julie D. Trachman and Subhro Ganguly and Seymour J. Garte},
  journal={Cancer detection and prevention},
  year={1999},
  volume={23 3},
  pages={
          232-7
        }
}
The endogenous metabolism of estrogens is primarily oxidative and involves hydroxylation of the steroid at either C2 (2-OHE1) or C16 (16-OHE1). While the 2-OHE1 metabolites are essentially devoid of peripheral biological activity, 16-OHE1 is an estrogen agonist. There is evidence of an association between the 2-OHE1/16-OHE1 metabolites ratio and breast cancer risk. The CYP1A1 gene may play a role in the 2-hydroxylation (2-OH) of estradiol. African-American women with the wild-type CYP1A1 gene… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 49 CITATIONS

Similar Papers

Loading similar papers…