Role of epsin 1 in synaptic vesicle endocytosis.

@article{Jakobsson2008RoleOE,
  title={Role of epsin 1 in synaptic vesicle endocytosis.},
  author={J. Herman Jakobsson and Helge Gad and Fredrik W. Andersson and Peter L{\"o}w and Oleg Shupliakov and L. Brodin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 17},
  pages={
          6445-50
        }
}
Epsin has been suggested to act as an alternate adaptor in several endocytic pathways. Its role in synaptic vesicle recycling remains, however, unclear. Here, we examined the role of epsin in this process by using the lamprey reticulospinal synapse as a model system. We characterized a lamprey ortholog of epsin 1 and showed that it is accumulated at release sites at rest and also at clathrin-coated pits in the periactive zone during synaptic activity. Disruption of epsin interactions, by… CONTINUE READING

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