Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.

@article{Logt2006RoleOE,
  title={Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.},
  author={Elise M. J. van der Logt and Saskia M. Bergevoet and Hennie M. J. Roelofs and Rene te Morsche and Yvo van Dijk and Theo Wobbes and Fokko M. Nagengast and Wilbert H. M. Peters},
  journal={Mutation research},
  year={2006},
  volume={593 1-2},
  pages={39-49}
}
Colorectal cancer (CRC) is one of the most common forms of cancer in Western countries. CRC has been associated with genetic and lifestyle factors. Individual susceptibility to CRC may be due partly to variations in detoxification capacity in the gastrointestinal tract. Genetic polymorphisms in detoxification enzymes may result in variations in detoxification activities, which subsequently might influence the levels of toxic/carcinogenic compounds, and this may influence the risk for CRC… CONTINUE READING