Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin.

@article{Fathallah2007RoleOE,
  title={Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin.},
  author={Hassana Fathallah and Rona Singer Weinberg and Yelena Galperin and Millicent Sutton and George F. Atweh},
  journal={Blood},
  year={2007},
  volume={110 9},
  pages={
          3391-7
        }
}
Butyrate is a prototype of histone deacetylase inhibitors that is believed to reactivate silent genes by inducing epigenetic modifications. Although butyrate was shown to induce fetal hemoglobin (HbF) production in patients with hemoglobin disorders, the mechanism of this induction has not been fully elucidated. Our studies of the epigenetic configuration of the beta-globin cluster suggest that DNA methylation and histone H3 acetylation are important for the regulation of developmental stage… CONTINUE READING

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