Role of epidermal growth factor receptor activation in regulating mucin synthesis

@article{Nadel2001RoleOE,
  title={Role of epidermal growth factor receptor activation in regulating mucin synthesis},
  author={Jay A. Nadel},
  journal={Respiratory Research},
  year={2001},
  volume={2},
  pages={85 - 89}
}
Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-cell metaplasia from Clara cells by a process of cell differentiation. These cells are also believed to be the cells of origin of non-small-cell lung cancer, but this occurs via cell… CONTINUE READING

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Cystic fibrosis.7 In: Textbook of Respiratory Medicine, 3rd ed

  • RC Boucher, MR Knowles, JR Yankaskas
  • Edited by Murray JF, Nadel JA. Philadelphia,
  • 2000
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