Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy.

@article{Seth1993RoleOE,
  title={Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy.},
  author={R Seth and Lillian Shum and Fangting Wu and Carol W. Wuenschell and Frederick L. Hall and Harold C. Slavkin and Dorothy Warburton},
  journal={Developmental biology},
  year={1993},
  volume={158 2},
  pages={
          555-9
        }
}
Epidermal growth factor (EGF) expression and branching morphogenesis were inhibited using a 5' 15-mer antisense oligodeoxynucleotide (ODN) directed against EGF precursor mRNA in embryonic mouse lung in culture under chemically defined, serumless conditions. Antisense EGF ODN resulted in > 90% inhibition of EGF immunoreactive peptide synthesis, 75% reduction in branching morphogenesis, 73% decrease in DNA content, 64% decrease in RNA content, 73% decrease in protein synthesis, and 65% decrease… CONTINUE READING

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