Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores

@article{Rossmeisl2004RoleOE,
  title={Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores},
  author={Martin Rossmeisl and Pavel Flachs and Petr Brauner and Jana Sponarov{\'a} and Olga Matejkova and Tom{\'a}s Praz{\'a}k and Jana Rů{\vz}i{\vc}kov{\'a} and Kristina Bardov{\'a} and Ondrej Kuda and Jan Kopeck{\'y}},
  journal={International Journal of Obesity},
  year={2004},
  volume={28},
  pages={S38-S44}
}
As indicated by in vitro studies, both lipogenesis and lipolysis in adipocytes depend on the cellular ATP levels. Ectopic expression of mitochondrial uncoupling protein 1 (UCP1) in the white adipose tissue of the aP2-Ucp1 transgenic mice reduced obesity induced by genetic or dietary manipulations. Furthermore, respiratory uncoupling lowered the cellular energy charge in adipocytes, while the synthesis of fatty acids (FA) was inhibited and their oxidation increased. Importantly, the complex… CONTINUE READING

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