Role of endothelium in thrombosis and hemostasis.

  title={Role of endothelium in thrombosis and hemostasis.},
  author={Kenneth K. Wu and Perumal Thiagarajan},
  journal={Annual review of medicine},
Vascular endothelium is strategically located at the interface between tissue and blood. It is pivotal for protecting against vascular injury and maintaining blood fluidity. Normal endothelium releases prostacyclin and nitric oxide, potent inhibitors of platelet and monocyte activation and vasodilators. Their syntheses are governed by isoforms of enzymes. Normal endothelial surface expresses ecto-adenosine diphosphatase, which degrades adenosine diphosphate and inhibits platelet aggregation… CONTINUE READING
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