Role of endothelium in the response to endothelin in hypertension.

@article{Wu1990RoleOE,
  title={Role of endothelium in the response to endothelin in hypertension.},
  author={Chau Chung Wu and David F. Bohr},
  journal={Hypertension},
  year={1990},
  volume={16 6},
  pages={
          677-81
        }
}
The relation between endothelin and acetylcholine (ACh) was examined and compared in aortas from Wistar-Kyoto (WKY) rats and from stroke-prone spontaneously hypertensive rats (SHRSP). The relaxation produced by ACh in an endothelin-induced contraction was less in aortas from WKY rats than in those from SHRSP. In aortas from WKY rats but not in those from SHRSP, the contraction produced by endothelin was augmented when the intact aortic rings were treated with methylene blue (10(-5) M). This… CONTINUE READING

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