Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction.

  title={Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction.},
  author={L M Lin and Alberto Nasjletti},
  volume={18 2},
To test the hypothesis that prostanoids contribute to angiotensin II-induced vascular contraction, we compared the effect of angiotensin II on isometric tension development by rings of descending thoracic aorta bathed in Krebs' bicarbonate buffer with and without indomethacin (10 microM) to inhibit cyclooxygenase, CGS13080 (10 microM) to inhibit thromboxane A2 synthesis, or SQ29548 (1 microM) to block thromboxane A2/prostaglandin endoperoxide receptors. The comparisons were made in rings of… CONTINUE READING
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Role of prostanoids in renin-dependent and renin-independent hypertension

  • L Lin, M Mistry, CT JrStier, A Nasjletti
  • Hypertension
  • 1991
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