Role of endothelin receptor subtypes in the in vivo regulation of renal function.

@article{Clavell1995RoleOE,
  title={Role of endothelin receptor subtypes in the in vivo regulation of renal function.},
  author={Alfredo L. Clavell and Andrew J. Stingo and Kenneth B. Margulies and Roland R. Brandt and John C Jr. Burnett},
  journal={The American journal of physiology},
  year={1995},
  volume={268 3 Pt 2},
  pages={
          F455-60
        }
}
Endothelin (ET) is a potent vasoconstrictor peptide of endothelial origin, which at low doses results in renal vasoconstriction and diuresis with variable actions on sodium excretion. The current study conducted in four groups of anesthetized dogs was designed to define the role of the ETA and ETB receptor subtypes in the renal actions of low-dose exogenous ET. Group 1 (n = 4) animals served as time controls. In group 2 (n = 6) a systemic ET-1 (5 ng.kg-1.min-1) infusion mediated renal… CONTINUE READING
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