Role of endothelin receptor subtypes in the behavioral effects of the intracerebroventricular administration of endothelin-1 in conscious rats.

@article{Nagasaka1999RoleOE,
  title={Role of endothelin receptor subtypes in the behavioral effects of the intracerebroventricular administration of endothelin-1 in conscious rats.},
  author={J Nagasaka and Minoru Tsuji and Hiroshi Takeda and Teruhiko Matsumiya},
  journal={Pharmacology, biochemistry, and behavior},
  year={1999},
  volume={64 1},
  pages={171-6}
}
The role of endothelin receptor subtypes, i.e., ET(A) and ET(B) receptors, in the behavioral effects of the intracerebroventricular (ICV) administration of endothelin-1 were examined in conscious rats. ICV administration of endothelin-1 (1-9 pmol/rat) dose dependently produced barrel rolling and other convulsive behaviors including bodily twitching, rigidity, back crawling, fore/hindlimb dystonia, fore/hindlimb clonus, tail extension, and facial clonus. Moreover, a marked increase in… CONTINUE READING