Role of endothelin in cardiovascular disease

@article{Agapitov2002RoleOE,
  title={Role of endothelin in cardiovascular disease},
  author={Alexei V. Agapitov and William G. Haynes},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  year={2002},
  volume={3},
  pages={1 - 15}
}
Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it influences salt and water homeostasis through its effects on the renin-angiotensin-aldosterone system… Expand
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179 Citations
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179 Citations

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Endothelin antagonists in hypertension and kidney disease
TLDR
Experimental evidence and recent clinical studies suggest that endothelin receptor blockade, in particular selective ETAR blockade, holds promise in the treatment of hypertension, proteinuria, and diabetes. Expand
Endothelin ETA receptor antagonism in cardiovascular disease.
TLDR
The role of ET-1 in cardiovascular modulation and the therapeutic potential of endothelin receptor antagonism are summarized. Expand
Pathophysiological roles of endothelin receptors in cardiovascular diseases.
TLDR
The current understanding regarding the role of ET receptors, especially the ET(B) receptor, in CVD is summarized. Expand
Endothelin Antagonism Suppresses Plasma and Cardiac Endothelin-1 Levels in SHRSPs at the Typical Hypertensive Stage
TLDR
Investigation of the effects of ET blockade on the expression levels of plasma and cardiac ET-1 in SHRSPs found that suppression of the upregulated ET system might be beneficial in arresting cardiac remodeling. Expand
Endothelin Receptor Blockers in Cardiovascular Disease
TLDR
The endothelin (ET) system is comprised of 4 active ETs, with ET-1 being the predominant isoform in the cardiovascular system, and the nonselective ET receptor antagonist bosentan improves exercise capacity and increases time to clinical worsening in patients with pulmonary arterial hypertension. Expand
Inhibition of ENaC by endothelin-1.
TLDR
Inhibition of ENaC by endothelin-1 (ET-1) has been established in renal cells, and several molecular mechanisms of inhibition of EN aC by ET-1 are proposed and will be reviewed in this chapter. Expand
Endothelin-1 and H2O2-induced signaling in vascular smooth muscle cells : modulation by CaMKII and Nitric oxide
Endothelin-1 has emerged as an extremely potent vasoactive peptide exhibiting potent mitogenic activity in vascular smooth muscle cells (VSMCs). A critical role of ET-1 in many cardiovascular… Expand
Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
TLDR
It is demonstrated that there is increased ETB and AT1 receptor expression in VSMC in ischemic heart disease and in GCA which correlates with the degree of inflammation. Expand
Expression of Endothelin-1 by Stimulation with CXCL8 in Mouse Peritoneal Macrophages
TLDR
Investigation of the role of IL-8/CXCL8, as a major inflammatory chemokine, for ET-1 expression in macrophges suggests it can act as one of main inducers ofET-1 in vascular inflammatory reactions, and ET- 1 expression by IL- 8/CxCL8 is related to 12-LO pathway in PeMφ. Expand
Pericardial fluid of cardiac patients elicits arterial constriction: role of endothelin-1.
TLDR
It is demonstrated that PFs of patients elicit substantial arterial constrictions, which is mediated primarily by ET-1, which could be a potential therapeutic target to improve coronary blood flow in cardiac patients. Expand
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References

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TLDR
According to this study, endothelin-1 participates in volume homeostasis in human, whereas pathophysiological concentrations can contribute to renal vasoconstriction and sodium retention, and calcium channel blockers may protect against these effects of endothelins-1. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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