Role of endothelin in cardiovascular disease

  title={Role of endothelin in cardiovascular disease},
  author={Alexei V. Agapitov and William G. Haynes},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  pages={1 - 15}
Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it influences salt and water homeostasis through its effects on the renin-angiotensin-aldosterone system… 

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