Role of endothelin in cardiovascular disease
@article{Agapitov2002RoleOE, title={Role of endothelin in cardiovascular disease}, author={Alexei V. Agapitov and William G. Haynes}, journal={Journal of the Renin-Angiotensin-Aldosterone System}, year={2002}, volume={3}, pages={1 - 15} }
Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it influences salt and water homeostasis through its effects on the renin-angiotensin-aldosterone system…
190 Citations
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Experimental evidence and recent clinical studies suggest that endothelin receptor blockade, in particular selective ETAR blockade, holds promise in the treatment of hypertension, proteinuria, and diabetes.
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Pathophysiological roles of endothelin receptors in cardiovascular diseases.
- Biology, MedicineJournal of pharmacological sciences
- 2012
The current understanding regarding the role of ET receptors, especially the ET(B) receptor, in CVD is summarized.
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Investigation of the effects of ET blockade on the expression levels of plasma and cardiac ET-1 in SHRSPs found that suppression of the upregulated ET system might be beneficial in arresting cardiac remodeling.
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- 2003
The endothelin (ET) system is comprised of 4 active ETs, with ET-1 being the predominant isoform in the cardiovascular system, and the nonselective ET receptor antagonist bosentan improves exercise capacity and increases time to clinical worsening in patients with pulmonary arterial hypertension.
Endothelin-1 and H2O2-induced signaling in vascular smooth muscle cells : modulation by CaMKII and Nitric oxide
- Biology, Chemistry
- 2010
A role of CaMKII in mediatingET-1 and H2O2induced ERK1/2, PKB, Pyk2 phosphorylation, as well as its effect on hypertrophic and proliferative responses of ET-1 in VSMCs remains unexplored.
Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
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It is demonstrated that there is increased ETB and AT1 receptor expression in VSMC in ischemic heart disease and in GCA which correlates with the degree of inflammation.
Expression of Endothelin-1 by Stimulation with CXCL8 in Mouse Peritoneal Macrophages
- Biology, Chemistry
- 2009
Investigation of the role of IL-8/CXCL8, as a major inflammatory chemokine, for ET-1 expression in macrophges suggests it can act as one of main inducers ofET-1 in vascular inflammatory reactions, and ET- 1 expression by IL- 8/CxCL8 is related to 12-LO pathway in PeMφ.
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BACKGROUND
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