Role of endothelin in cardiovascular disease

@article{Agapitov2002RoleOE,
  title={Role of endothelin in cardiovascular disease},
  author={Alexei V. Agapitov and William G. Haynes},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  year={2002},
  volume={3},
  pages={1 - 15}
}
Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it influences salt and water homeostasis through its effects on the renin-angiotensin-aldosterone system… Expand
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TLDR
Investigation of the role of IL-8/CXCL8, as a major inflammatory chemokine, for ET-1 expression in macrophges suggests it can act as one of main inducers ofET-1 in vascular inflammatory reactions, and ET- 1 expression by IL- 8/CxCL8 is related to 12-LO pathway in PeMφ. Expand
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