Role of endothelin and tumour necrosis factor in the renal response to sepsis.

  • Donald E Kohan
  • Published 1994 in
    Nephrology, dialysis, transplantation : official…
A rapidly increasing body of evidence is implicating endothelin and TNF in the pathogenesis of septic acute renal failure. TNF causes renal damage by recruiting leukocytes, accelerating fibrin accumulation, promoting cell lysis, stimulating the release of vasoconstrictor substances, and other mechanisms. ET-1 causes renal dysfunction in sepsis and… CONTINUE READING