Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries.

@article{Kinlay2001RoleOE,
  title={Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries.},
  author={Scott Kinlay and Dominik Behrendt and Marco Wainstein and John F. Beltrame and James Chen-Tson Fang and Mark A. Creager and Andrew P Selwyn and Peter A Ganz},
  journal={Circulation},
  year={2001},
  volume={104 10},
  pages={1114-8}
}
BACKGROUND Atherosclerotic coronary arteries are prone to constriction but the underlying causes are incompletely understood. We tested the hypothesis that endothelin-1 (ET-1), a potent vasoconstrictor, contributes to the heightened tone of atherosclerotic human coronary arteries. METHODS AND RESULTS In 8 patients with coronary artery disease (CAD) and 8 patients with angiographically smooth coronary arteries (normal), we infused BQ-123, an antagonist of the ET(A) receptor, into a major… CONTINUE READING

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