Role of endothelin-1 in osteoblastic bone metastases.

  title={Role of endothelin-1 in osteoblastic bone metastases.},
  author={Theresa A. Guise and Juan Yin and Khalid S. Mohammad},
  volume={97 3 Suppl},
BACKGROUND Certain solid tumors metastasize to bone and cause an osteoblastic response. The mechanisms by which tumor cells stimulate this new bone formation are not completely understood. METHODS The authors identified three breast cancer lines that cause osteoblastic metastases in female nude mice and provided evidence that tumor-produced endothelin-1… CONTINUE READING