Role of endothelin-1 in lung disease

  title={Role of endothelin-1 in lung disease},
  author={Karen A. Fagan and Ivan F. McMurtry and David M. Rodman},
  journal={Respiratory Research},
  pages={90 - 101}
Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease. 

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