Role of endothelial nitric oxide synthase in the regulation of SREBP activation by oxidized phospholipids.

@article{Gharavi2006RoleOE,
  title={Role of endothelial nitric oxide synthase in the regulation of SREBP activation by oxidized phospholipids.},
  author={Nima M Gharavi and Nancy A. Baker and Kevin P. Mouillesseaux and Winnie M. M. Yeung and Henry M. Honda and Xavier Hsieh and Michael Yeh and Eric J. Smart and Judith A. Berliner},
  journal={Circulation research},
  year={2006},
  volume={98 6},
  pages={768-76}
}
Oxidized-1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (Ox-PAPC), found in atherosclerotic lesions and other sites of chronic inflammation, activates endothelial cells (EC) to synthesize chemotactic factors, such as interleukin (IL)-8. Previously, we demonstrated that the sustained induction of IL-8 transcription by Ox-PAPC was mediated through the activation of sterol regulatory element-binding protein (SREBP). We now present evidence for the role of endothelial nitric oxide… CONTINUE READING

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