Role of endothelial nitric oxide synthase in endothelial cell migration.

@article{Murohara1999RoleOE,
  title={Role of endothelial nitric oxide synthase in endothelial cell migration.},
  author={Toyoaki Murohara and Bernhard Witzenbichler and Ioakim Spyridopoulos and Takayuki Asahara and Bo Ding and Angela Sullivan and Douglas W. Losordo and Jeffrey M. Isner},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 5},
  pages={1156-61}
}
Endothelium-derived nitric oxide (NO) and its precursor L-arginine have been implied to promote angiogenesis, but little is known about the precise mechanism. The inhibition of endogenous NO formation by Nomega-nitro-L-arginine methyl ester (L-NAME) (1 mmol/L) but not its inactive enantiomer D-NAME (1 mmol/L) inhibited endothelial cell sprouting from the scratched edge of the cultured bovine aortic endothelial cell monolayer. Inhibition of endogenous NO release by L-NAME was confirmed by… CONTINUE READING