Role of endoscopy and biopsy in the work up of dyspepsia

@article{Tytgat2002RoleOE,
  title={Role of endoscopy and biopsy in the work up of dyspepsia},
  author={Guido N. J. Tytgat},
  journal={Gut},
  year={2002},
  volume={50},
  pages={iv13 - iv16}
}
Endoscopy is recommended as the first investigation in the work up of a patient with dyspeptic symptoms and is essential in the classification of the patient's condition as organic or functional dyspepsia. Although the correlation between mucosal alterations and symptom pattern is difficult, endoscopy will remain the initial investigation of choice for clinically relevant abnormalities that need proper detection and biopsy. 
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There are clear indications to biopsy suspicious ulceration or mass lesions and for investigation of some inflammatory conditions, such as eosinophilic oesophagitis and coeliac disease, but outside these areas, the endoscopist should consider whether biopsy of normal or abnormal appearing mucosa is likely to contribute to patient management, to ensure effective use of limited healthcare resources.
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TLDR
The endoscopic diagnosis of persistent dyspepsia in this setting showed a predominance of functional disease, whereas UGI malignancy was an uncommon finding.
[Diagnosis of functional dyspepsia: a systematic review].
This review tried to set up an initial diagnostic strategy in patients with functional dyspepsia. Dyspepsia was defined as chronic or recurrent pain, or discomfort centered in the upper abdomen
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TLDR
Endoscopy is the diagnostic procedure of choice in the evaluation of upper gastrointestinal symptoms and remains the “gold standard” by evaluating all cases of dyspepsia by scopy and serious pathology like malignancy may not be missed at earlier stage thus reducing morbidity and mortality.
Low Prevalence of Clinically Significant Endoscopic Findings in Outpatients with Dyspepsia
TLDR
Dyspeptic patients have low prevalence of SEFs and the presence of any alarm feature and age ≥ 55 are associated with higher risk of SEF; these patients can be considered for nonendoscopic approach for diagnosis and management.
Functional dyspepsia in Yola, Nigeria
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Dyspepsia is a common disorder originating from the upper gastrointestinal tract, and is the most common indication for gastrointestinal endoscopy, and it has profound clinical and economic effects, and influences the quality of life of sufferers.
Duodenal lymphocytosis in functional dyspepsia.
  • A. Capannolo, S. Necozione, G. Frieri
  • Medicine
    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
  • 2019
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TLDR
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