Role of endogenous nitric oxide in mucosal defense of inflamed rat stomach following iodoacetamide treatment.

@article{Nishio2006RoleOE,
  title={Role of endogenous nitric oxide in mucosal defense of inflamed rat stomach following iodoacetamide treatment.},
  author={Hikaru Nishio and Yujiro Hayashi and Shun Terashima and Koji Takeuchi},
  journal={Life sciences},
  year={2006},
  volume={79 16},
  pages={1523-30}
}
Nitric oxide (NO) plays a role in regulating the mucosal integrity of the stomach. However, its part in the mucosal defense of the inflamed stomach remains unclear. In the present study, we examined the effects of various NO synthase (NOS) inhibitors on gastric ulcerogenic and acid secretory responses following daily exposure of the stomach to iodoacetamide and investigated the role of each NOS isozyme in gastric protection from subchronic mucosal irritation. Gastric mucosal irritation was… CONTINUE READING

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