Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators.

@article{Kageyama1997RoleOE,
  title={Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators.},
  author={Norihito Kageyama and Mamoru Miura and Makoto Ichinose and Masafumi Tomaki and Jun Ishikawa and Yasufumi Ohuchi and Norio Endoh and Kunio Shirato},
  journal={The European respiratory journal},
  year={1997},
  volume={10 1},
  pages={13-9}
}
This study examines the role of endogenous nitric oxide (NO) in airway microvascular leakage induced inflammatory mediators, which play an important role in asthmatic airways. Guinea-pigs were anesthetized and mechanically-ventilated with monitoring of arterial blood pressure, and airway microvascular leakage induced by intravenous injection of substance P (SP), leukotriene D4 (LTD4) and histamine was evaluated using Evans blue dye and Monastral blue dye in the presence and absence of the NO… CONTINUE READING