Role of endogenous gastrin in gastroprotection.

@article{Konturek1995RoleOE,
  title={Role of endogenous gastrin in gastroprotection.},
  author={Stanisław Jan Konturek and Tomasz Brzozowski and Wladyslaw Bielański and Andrew V Schally},
  journal={European journal of pharmacology},
  year={1995},
  volume={278 3},
  pages={203-12}
}
Gastrin has a potent influence on gastric acid secretion and mucosal growth but its role in mucosal integrity has been little studied. This study investigated in rats whether gastrin protects the gastric mucosa against the damage by 100% ethanol and what are the possible mechanisms of this protection. Exogenous gastrin-17 (0.6-5.0 pmol/kg) injected subcutaneously (s.c.) reduced dose dependently ethanol-induced mucosal damage and the dose decreasing the ethanol lesions by 50% was about 1.8 pmol… CONTINUE READING

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