Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

  title={Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.},
  author={Douglas M. Stone and Mark D Johnson and Glen R. Hanson and James W. Gibb},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={247 1},
Similar to other amphetamine analogs 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"), a currently popular illicit drug, has been characterized recently as a serotonergic neurotoxin due to its ability to cause long-lasting deficits in markers of central serotonergic function in animals. Because the serotonergic toxicity associated with the MDMA analog methamphetamine has been linked previously to endogenous dopamine and because MDMA, like methamphetamine, elicits pronounced dopamine release… CONTINUE READING


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serotonin pathways in brain of ret

  • Mwt, C J Rrrrer, J K Sonsali, P K Hanson, G R Andgidi
  • Neuropharmacology
  • 1987

Immediate by neostriatai serotonergic neurons of the rat

  • Cxmid 'r, C J Andlovenberg, +4 authors G R Andgrab
  • NeuroecL Lett
  • 1985

Influence of dopamine synthesis on methamcinogenic amphetamine Selectively destroys brain aerotouin nerve termlnslw. phetamine-induced changes in striatal and adrenal tyresine hydroxylase

  • Ricauete, G Bryan, +4 authors J W And Kooan
  • 1Van- Science (Wash. DC)
  • 1985

The effects of pharmacoL Exp4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedinx-jam- phetamine (MDA) on monoaminergic systems in the rat brain

  • W J Role Of Dopamine In The Neurotoxic Effects Of Meth, D M Stone, D C Stahl, G R Hanson, J W And Gib
  • V. L.: Depression of mt brain tryptophan…
  • 1985

Behavioral properties of GBR 12909 13069 and GBR 13098: Specific inhibitere of dopamine uptake Failure to detect 6-hydroxydopamine in rat striatum after the macol

  • H_Kkila, R E And Manz ! No, L Gbr Rollema, De Vines, J B Westeeink, H C Vanptrrren
  • Behavioral properties of GBR 12909 13069 and GBR…
  • 1984

Effect of cyeteine on the persistent depletion of brain mopoaminee by amphetamine, p-chloroamphetamine and MPTP. Eur. mer0wnsrgicsystems to methamphetamine

  • Steranka hlorophenylalanine On The Neurotoxic Response Of T, L R Andrhind
  • Fed. Proc. J. PharmacoL
  • 1983

Chemical release of dopamine from str Parkineon's diSease: A disorder homogeDates: Evidence for an exchange diffusion model

  • J F Fischer, And, A K Cho, T L Perry, D V Odin, S Hansen
  • J. Pharmecol. EXP. due to nigral glutethione…
  • 1982

nyn-schmiedeberg's Arch. Pharmacol

  • nyn-schmiedeberg's Arch. Pharmacol
  • 1979

Long-term effects of multiple doses oir meth- Acta Pharmaeol

  • Hotchkiss, A Gme
  • Toxicol
  • 1978

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