Role of endogenous PGE2 in osteoblastic functions of a clonal osteoblast-like cell, MC3T3-E1.

@article{Igarashi1994RoleOE,
  title={Role of endogenous PGE2 in osteoblastic functions of a clonal osteoblast-like cell, MC3T3-E1.},
  author={Kazuhiko Igarashi and Masahiko Hirafuji and Hirotoshi Adachi and Hisashi Shinoda and Hideo Mitani},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1994},
  volume={50 4},
  pages={169-72}
}
MC3T3-E1 cells actively synthesized and released prostaglandin E2 (PGE2) during culture. PGE2 release was minimal on day 9 and gradually increased with culture up to day 27. DNA content gradually increased until day 27. Alkaline phosphatase (ALP) activity increased up to day 15 and decreased thereafter. In contrast to the decrease in ALP activity, calcium accumulation increased rapidly after day 21, possibly due to mineralization by the cells. Indomethacin, a cyclooxygenase inhibitor, blocked… CONTINUE READING
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