Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier.

Abstract

This study examined the metabolism of arachidonic acid (AA) by cytochrome P-450 enzymes in isolated glomeruli and the effects of selective inhibitors of the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatetraenoic acids (EETs) on glomerular permeability to albumin (P(alb)). Glomeruli avidly produced 20-HETE, EETs… (More)

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@article{Williams2007RoleOE, title={Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier.}, author={Jan Michael Williams and Mukut Lal Sharma and Siddam Anjaiahh and John R Falck and Richard J. Roman}, journal={American journal of physiology. Renal physiology}, year={2007}, volume={293 2}, pages={F501-5} }