Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.

@article{Hazbn2005RoleOE,
  title={Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.},
  author={Manzour Hernando Hazb{\'o}n and Miriam Bobadilla del Valle and Marta In{\'i}rida Guerrero and Mandira Varma-Basil and Ingrid Filliol and Magali Cavatore and Roberto Colangeli and Hassan Safi and Helen Billman-Jacobe and Caroline Lavender and Janet Fyfe and Lourdes Garc{\'i}a-Garc{\'i}a and Amy L Davidow and Michael B Brimacombe and Clara In{\'e}s Le{\'o}n and Tania Bibiana Porras and Mridula Bose and Fernando Chaves and Kathleen Eisenach and Jos{\'e} Sifuentes-Osornio and Alfredo Ponce de Le{\'o}n and M. Donald Cave and David Alland},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 9},
  pages={
          3794-802
        }
}
Mutations at position 306 of embB (embB306) have been proposed as a marker for ethambutol resistance in Mycobacterium tuberculosis; however, recent reports of embB306 mutations in ethambutol-susceptible isolates caused us to question the biological role of this mutation. We tested 1,020 clinical M. tuberculosis isolates with different drug susceptibility patterns and of different geographical origins for associations between embB306 mutations, drug resistance patterns, and major genetic group… CONTINUE READING

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Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis.

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