Role of electrogenic Na+ pump in the response of sensitized airway smooth muscle to antigen.

Airway smooth muscle (ASM) preparations (mid-cervical portion of trachea) were isolated from control Camm-Hartley male guinea pigs and from animals repeatedly sensitized by ovalbumin. Simultaneously with the measurement of isometric force developed by ASM preparations, resting membrane potential (Em) was determined by employing a conventional microelectrode… (More)