Role of eicosanoids in the pathogenesis of murine cerebral malaria.

  title={Role of eicosanoids in the pathogenesis of murine cerebral malaria.},
  author={Lihua Xiao and Paige Patterson and C Yang and Altaf A. Lal},
  journal={The American journal of tropical medicine and hygiene},
  volume={60 4},
Because microvascular damage is a common feature of cerebral malaria, we have examined the role eicosanoid metabolites (prostaglandins and leukotrienes) in experimental cerebral malaria. Eighty ICR mice were infected with Plasmodium berghei ANKA, with 40 uninfected mice as controls. Half of the infected mice were treated on days 4 and 5 with aspirin, a prostaglandin synthesis inhibitor. Infected mice started to die of cerebral malaria on day 6, and by day 17, all infected mice died. In contrast… CONTINUE READING
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