Role of eicosanoids in structural degradation in osteoarthritis

  title={Role of eicosanoids in structural degradation in osteoarthritis},
  author={Stefan A. Laufer},
  journal={Current Opinion in Rheumatology},
  • S. Laufer
  • Published 1 September 2003
  • Medicine, Biology
  • Current Opinion in Rheumatology
Purpose of reviewOsteoarthritis is characterized mainly by degenerative changes in joint cartilage, ultimately resulting in loss of cartilage, and alterations in the subchondral bone. Osteoarthritis osteoblasts show a number of metabolic alterations that may interfere with normal cell metabolism and signaling, possibly leading to altered extracellular matrix composition. This review examines the role of eicosanoids in this structural degradation. Recent findingsProstaglandins exert diverse… 

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The role of nitric oxide in articular cartilage damage.

  • M. Lotz
  • Biology, Medicine
    Rheumatic diseases clinics of North America
  • 1999

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