Role of eicosanoids in renal angiotensin II vasoconstriction during nitric oxide blockade.

@article{Muller1998RoleOE,
  title={Role of eicosanoids in renal angiotensin II vasoconstriction during nitric oxide blockade.},
  author={Christian D Muller and Karlhans Endlich and J. J. Helwig},
  journal={Kidney international. Supplement},
  year={1998},
  volume={67},
  pages={S234-7}
}
Nitric oxide (NO) buffers the effect of vasoconstrictors currently active in the renovascular system. Enhancement of the angiotensin II (Ang II)-induced vasoconstriction during NO blockade comprises both AT2-sensitive potentiation, decreasing the half maximal vasoconstriction (EC50) value to the subnanomolar concentration range, and augmentation, increasing the maximal effect (Emax) value in the isolated perfused rat kidney. In this study, we examine whether constrictory prostanoids are… CONTINUE READING