Role of early reperfusion in the induction of adhesion molecules and cytokines in previously ischemic myocardium

  title={Role of early reperfusion in the induction of adhesion molecules and cytokines in previously ischemic myocardium},
  author={Gilbert L. Kukielka and Keith A. Youker and Lloyd H. Michael and A Gururaj Kumar and Christie M. Ballantyne and Clifton Smith and Mark L. Entman},
  journal={Molecular and Cellular Biochemistry},
Our studiesin vitro demonstrate that neutrophil mediated injury of isolated cardiac myocytes requires the presence of ICAM-1 on the surface of the myocyte and CD11b/CD18 activation on the neutrophil. In post-ischemic cardiac lymph, there is rapid appearance of C5a activity during the first hours of reperfusion. Interleukin-6 activity is present throughout the first 72 h of reperfusion and is sufficient to induce ICAM-1 on the surface of the cardiac myocyte.In situ hybridization studies suggest… CONTINUE READING


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