Role of eIF4E in stimulation of protein synthesis by IGF-I in perfused rat skeletal muscle.

@article{Vary2000RoleOE,
  title={Role of eIF4E in stimulation of protein synthesis by IGF-I in perfused rat skeletal muscle.},
  author={Thomas C. Vary and Leonard S. Jefferson and Scot R. Kimball},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={278 1},
  pages={E58-64}
}
Insulin-like growth factor I (IGF-I) promotes anabolism by stimulating protein synthesis in skeletal muscle. In the present study, we have examined mechanisms by which IGF-I stimulates protein synthesis in skeletal muscle with a perfused rat hindlimb preparation. IGF-I (10 nM) stimulated protein synthesis over 2.7-fold. Total RNA content was unaffected, but translational efficiency was increased by IGF-I. We next examined the effect of IGF-I on eukaryotic initiation factor (eIF) 4E as a… CONTINUE READING

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