Role of dual-energy CT in the diagnosis and follow-up of gout: systematic analysis of the literature

  title={Role of dual-energy CT in the diagnosis and follow-up of gout: systematic analysis of the literature},
  author={Andr{\'e} Ramon and Am{\'e}lie Bohm-Sigrand and Pierre Pottecher and Pascal Richette and J. F. Maillefert and Herv{\'e} Devilliers and Paul Ornetti},
  journal={Clinical Rheumatology},
The aim of this systematic review was to determine the potential role of dual-energy CT in the diagnosis and follow-up of gout with regard to the Outcome Measures in Rheumatology (OMERACT) filter. A systematic analysis of the literature was conducted using the MEDLINE and Cochrane databases and published abstracts of international congresses, according to the criteria of the OMERACT filter: feasibility, reproducibility, validity versus laboratory (serum urate, MSU synovial fluid aspirate) and… 

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A glance into the future of gout

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Outcome Measures in Gout

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Clinical Applications of Spectral CT

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Volumetric reduction and dissolution prediction of monosodium urate crystal during urate-lowering therapy – a study using dual-energy computed tomography

MSU dissolution is better described as a logarithmic function of SU, which explains, predicts, and facilitates understanding of the dissolution process.

Highlights of the 23rd Annual Scientific Meeting of the Australasian Musculoskeletal Imaging Group (AMSIG) 2019, Queenstown, New Zealand

The Australasian Musculoskeletal Imaging Group (AMSIG) held its 23rd Annual Scientific Meeting (ASM) at the Millennium Hotel, Queenstown in the South Island of New Zealand over 2 days on the 30th and



Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study

DECT has a significant impact on clinical decision making when gout is suspected, but polarising microscopy of synovial fluid fails to demonstrate the presence of MSU crystals.

Dual energy CT in gout: a prospective validation study

The specificity was high, but sensitivity was more moderate, potentially due to frequent ULT use in the authors' patients, and prospective data indicate high reproducibility of DECT urate volume measures.

The application of dual-energy computed tomography in the diagnosis of acute gouty arthritis

DECT showed high sensitivity and specificity for the identification of urate crystals and diagnosis of acute gout, and Interestingly, urate volume was correlated with the disease duration, serum uric acid levels, the presence of tophi, and bone erosion.

Dual-energy computed tomography compared with ultrasound in the diagnosis of gout.

DECT and US have comparable sensitivity for the detection of gouty arthritis in a clinical setting, however, DECT results should be interpreted carefully, as there could be some false-negative findings.

Systemic staging for urate crystal deposits with dual-energy CT and ultrasound in patients with suspected gout

DECT is more specific for the diagnosis of gout than US, however, it fails to detect small urate crystal deposits, and might be particularly useful for patients with ambivalent findings, concomitant rheumatic diseases and with non-conclusive joint aspiration.

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High intraobserver reliability was found when applying the consensus-based ultrasound definitions of elementary gout lesions in patients on all elementary lesions while interob server reliability was moderate to low.

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In patients with tophaceous gout on stable conventional urate-lowering therapy the measurement error for DECT urate volume assessment is substantially greater than the median baseline DECT volume.